Pesquisa | Secretaria de Estado da Saúde

1.

B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV.

Scheid, Johannes F; Barnes, Christopher O; Eraslan, Basak; Hudak, Andrew; Keeffe, Jennifer R; Cosimi, Lisa A; Brown, Eric M; Muecksch, Frauke; Weisblum, Yiska; Zhang, Shuting; Delorey, Toni; Woolley, Ann E; Ghantous, Fadi; Park, Sung-Moo; Phillips, Devan; Tusi, Betsabeh; Huey-Tubman, Kathryn E; Cohen, Alexander A; Gnanapragasam, Priyanthi N P; Rzasa, Kara; Hatziioanno, Theodora; Durney, Michael A; Gu, Xiebin; Tada, Takuya; Landau, Nathaniel R; West, Anthony P; Rozenblatt-Rosen, Orit; Seaman, Michael S; Baden, Lindsey R; Graham, Daniel B; Deguine, Jacques; Bieniasz, Paul D; Regev, Aviv; Hung, Deborah; Bjorkman, Pamela J; Xavier, Ramnik J.

Cell ; 184(12): 3205-3221.e24, 2021 06 10.

Artigo Inglês | MEDLINE | ID: mdl-34015271

2.

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies.

Barnes, Christopher O; West, Anthony P; Huey-Tubman, Kathryn E; Hoffmann, Magnus A G; Sharaf, Naima G; Hoffman, Pauline R; Koranda, Nicholas; Gristick, Harry B; Gaebler, Christian; Muecksch, Frauke; Lorenzi, Julio C Cetrulo; Finkin, Shlomo; Hägglöf, Thomas; Hurley, Arlene; Millard, Katrina G; Weisblum, Yiska; Schmidt, Fabian; Hatziioannou, Theodora; Bieniasz, Paul D; Caskey, Marina; Robbiani, Davide F; Nussenzweig, Michel C; Bjorkman, Pamela J.

Cell ; 182(4): 828-842.e16, 2020 08 20.

Artigo Inglês | MEDLINE | ID: mdl-32645326

3.

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.

Schommers, Philipp; Gruell, Henning; Abernathy, Morgan E; Tran, My-Kim; Dingens, Adam S; Gristick, Harry B; Barnes, Christopher O; Schoofs, Till; Schlotz, Maike; Vanshylla, Kanika; Kreer, Christoph; Weiland, Daniela; Holtick, Udo; Scheid, Christof; Valter, Markus M; van Gils, Marit J; Sanders, Rogier W; Vehreschild, Jörg J; Cornely, Oliver A; Lehmann, Clara; Fätkenheuer, Gerd; Seaman, Michael S; Bloom, Jesse D; Bjorkman, Pamela J; Klein, Florian.

Cell ; 180(3): 471-489.e22, 2020 02 06.

Artigo Inglês | MEDLINE | ID: mdl-32004464

4.

Antibody-mediated neutralization of SARS-CoV-2.

Gruell, Henning; Vanshylla, Kanika; Weber, Timm; Barnes, Christopher O; Kreer, Christoph; Klein, Florian.

Immunity ; 55(6): 925-944, 2022 06 14.

Artigo Inglês | MEDLINE | ID: mdl-35623355

5.

Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins.

Wang, Zijun; Muecksch, Frauke; Cho, Alice; Gaebler, Christian; Hoffmann, Hans-Heinrich; Ramos, Victor; Zong, Shuai; Cipolla, Melissa; Johnson, Briana; Schmidt, Fabian; DaSilva, Justin; Bednarski, Eva; Ben Tanfous, Tarek; Raspe, Raphael; Yao, Kaihui; Lee, Yu E; Chen, Teresia; Turroja, Martina; Milard, Katrina G; Dizon, Juan; Kaczynska, Anna; Gazumyan, Anna; Oliveira, Thiago Y; Rice, Charles M; Caskey, Marina; Bieniasz, Paul D; Hatziioannou, Theodora; Barnes, Christopher O; Nussenzweig, Michel C.

Immunity ; 55(6): 998-1012.e8, 2022 06 14.

Artigo Inglês | MEDLINE | ID: mdl-35447092

6.

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.

Muecksch, Frauke; Weisblum, Yiska; Barnes, Christopher O; Schmidt, Fabian; Schaefer-Babajew, Dennis; Wang, Zijun; C Lorenzi, Julio C; Flyak, Andrew I; DeLaitsch, Andrew T; Huey-Tubman, Kathryn E; Hou, Shurong; Schiffer, Celia A; Gaebler, Christian; Da Silva, Justin; Poston, Daniel; Finkin, Shlomo; Cho, Alice; Cipolla, Melissa; Oliveira, Thiago Y; Millard, Katrina G; Ramos, Victor; Gazumyan, Anna; Rutkowska, Magdalena; Caskey, Marina; Nussenzweig, Michel C; Bjorkman, Pamela J; Hatziioannou, Theodora; Bieniasz, Paul D.

Immunity ; 54(8): 1853-1868.e7, 2021 08 10.

Artigo Inglês | MEDLINE | ID: mdl-34331873

7.

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.

Schoofs, Till; Barnes, Christopher O; Suh-Toma, Nina; Golijanin, Jovana; Schommers, Philipp; Gruell, Henning; West, Anthony P; Bach, Franziska; Lee, Yu Erica; Nogueira, Lilian; Georgiev, Ivelin S; Bailer, Robert T; Czartoski, Julie; Mascola, John R; Seaman, Michael S; McElrath, M Juliana; Doria-Rose, Nicole A; Klein, Florian; Nussenzweig, Michel C; Bjorkman, Pamela J.

Immunity ; 50(6): 1513-1529.e9, 2019 06 18.

Artigo Inglês | MEDLINE | ID: mdl-31126879

8.

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection.

Wang, Zijun; Muecksch, Frauke; Schaefer-Babajew, Dennis; Finkin, Shlomo; Viant, Charlotte; Gaebler, Christian; Hoffmann, Hans- Heinrich; Barnes, Christopher O; Cipolla, Melissa; Ramos, Victor; Oliveira, Thiago Y; Cho, Alice; Schmidt, Fabian; Da Silva, Justin; Bednarski, Eva; Aguado, Lauren; Yee, Jim; Daga, Mridushi; Turroja, Martina; Millard, Katrina G; Jankovic, Mila; Gazumyan, Anna; Zhao, Zhen; Rice, Charles M; Bieniasz, Paul D; Caskey, Marina; Hatziioannou, Theodora; Nussenzweig, Michel C.

Nature ; 595(7867): 426-431, 2021 07.

Artigo Inglês | MEDLINE | ID: mdl-34126625

9.

Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.

De Gasparo, Raoul; Pedotti, Mattia; Simonelli, Luca; Nickl, Petr; Muecksch, Frauke; Cassaniti, Irene; Percivalle, Elena; Lorenzi, Julio C C; Mazzola, Federica; Magrì, Davide; Michalcikova, Tereza; Haviernik, Jan; Honig, Vaclav; Mrazkova, Blanka; Polakova, Natalie; Fortova, Andrea; Tureckova, Jolana; Iatsiuk, Veronika; Di Girolamo, Salvatore; Palus, Martin; Zudova, Dagmar; Bednar, Petr; Bukova, Ivana; Bianchini, Filippo; Mehn, Dora; Nencka, Radim; Strakova, Petra; Pavlis, Oto; Rozman, Jan; Gioria, Sabrina; Sammartino, Josè Camilla; Giardina, Federica; Gaiarsa, Stefano; Pan-Hammarström, Qiang; Barnes, Christopher O; Bjorkman, Pamela J; Calzolai, Luigi; Piralla, Antonio; Baldanti, Fausto; Nussenzweig, Michel C; Bieniasz, Paul D; Hatziioannou, Theodora; Prochazka, Jan; Sedlacek, Radislav; Robbiani, Davide F; Ruzek, Daniel; Varani, Luca.

Nature ; 593(7859): 424-428, 2021 05.

Artigo Inglês | MEDLINE | ID: mdl-33767445

10.

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants.

Wang, Zijun; Schmidt, Fabian; Weisblum, Yiska; Muecksch, Frauke; Barnes, Christopher O; Finkin, Shlomo; Schaefer-Babajew, Dennis; Cipolla, Melissa; Gaebler, Christian; Lieberman, Jenna A; Oliveira, Thiago Y; Yang, Zhi; Abernathy, Morgan E; Huey-Tubman, Kathryn E; Hurley, Arlene; Turroja, Martina; West, Kamille A; Gordon, Kristie; Millard, Katrina G; Ramos, Victor; Da Silva, Justin; Xu, Jianliang; Colbert, Robert A; Patel, Roshni; Dizon, Juan; Unson-O'Brien, Cecille; Shimeliovich, Irina; Gazumyan, Anna; Caskey, Marina; Bjorkman, Pamela J; Casellas, Rafael; Hatziioannou, Theodora; Bieniasz, Paul D; Nussenzweig, Michel C.

Nature ; 592(7855): 616-622, 2021 04.

Artigo Inglês | MEDLINE | ID: mdl-33567448

11.

Evolution of antibody immunity to SARS-CoV-2.

Gaebler, Christian; Wang, Zijun; Lorenzi, Julio C C; Muecksch, Frauke; Finkin, Shlomo; Tokuyama, Minami; Cho, Alice; Jankovic, Mila; Schaefer-Babajew, Dennis; Oliveira, Thiago Y; Cipolla, Melissa; Viant, Charlotte; Barnes, Christopher O; Bram, Yaron; Breton, Gaëlle; Hägglöf, Thomas; Mendoza, Pilar; Hurley, Arlene; Turroja, Martina; Gordon, Kristie; Millard, Katrina G; Ramos, Victor; Schmidt, Fabian; Weisblum, Yiska; Jha, Divya; Tankelevich, Michael; Martinez-Delgado, Gustavo; Yee, Jim; Patel, Roshni; Dizon, Juan; Unson-O'Brien, Cecille; Shimeliovich, Irina; Robbiani, Davide F; Zhao, Zhen; Gazumyan, Anna; Schwartz, Robert E; Hatziioannou, Theodora; Bjorkman, Pamela J; Mehandru, Saurabh; Bieniasz, Paul D; Caskey, Marina; Nussenzweig, Michel C.

Nature ; 591(7851): 639-644, 2021 03.

Artigo Inglês | MEDLINE | ID: mdl-33461210

12.

Vaccine design via antigen reorientation.

Xu, Duo; Carter, Joshua J; Li, Chunfeng; Utz, Ashley; Weidenbacher, Payton A B; Tang, Shaogeng; Sanyal, Mrinmoy; Pulendran, Bali; Barnes, Christopher O; Kim, Peter S.

Nat Chem Biol ; 2024 Jan 15.

Artigo Inglês | MEDLINE | ID: mdl-38225471

13.

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.

Barnes, Christopher O; Jette, Claudia A; Abernathy, Morgan E; Dam, Kim-Marie A; Esswein, Shannon R; Gristick, Harry B; Malyutin, Andrey G; Sharaf, Naima G; Huey-Tubman, Kathryn E; Lee, Yu E; Robbiani, Davide F; Nussenzweig, Michel C; West, Anthony P; Bjorkman, Pamela J.

Nature ; 588(7839): 682-687, 2020 12.

Artigo Inglês | MEDLINE | ID: mdl-33045718

14.

Convergent antibody responses to SARS-CoV-2 in convalescent individuals.

Robbiani, Davide F; Gaebler, Christian; Muecksch, Frauke; Lorenzi, Julio C C; Wang, Zijun; Cho, Alice; Agudelo, Marianna; Barnes, Christopher O; Gazumyan, Anna; Finkin, Shlomo; Hägglöf, Thomas; Oliveira, Thiago Y; Viant, Charlotte; Hurley, Arlene; Hoffmann, Hans-Heinrich; Millard, Katrina G; Kost, Rhonda G; Cipolla, Melissa; Gordon, Kristie; Bianchini, Filippo; Chen, Spencer T; Ramos, Victor; Patel, Roshni; Dizon, Juan; Shimeliovich, Irina; Mendoza, Pilar; Hartweger, Harald; Nogueira, Lilian; Pack, Maggi; Horowitz, Jill; Schmidt, Fabian; Weisblum, Yiska; Michailidis, Eleftherios; Ashbrook, Alison W; Waltari, Eric; Pak, John E; Huey-Tubman, Kathryn E; Koranda, Nicholas; Hoffman, Pauline R; West, Anthony P; Rice, Charles M; Hatziioannou, Theodora; Bjorkman, Pamela J; Bieniasz, Paul D; Caskey, Marina; Nussenzweig, Michel C.

Nature ; 584(7821): 437-442, 2020 08.

Artigo Inglês | MEDLINE | ID: mdl-32555388

15.

Author Correction: SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.

Barnes, Christopher O; Jette, Claudia A; Abernathy, Morgan E; Dam, Kim-Marie A; Esswein, Shannon R; Gristick, Harry B; Malyutin, Andrey G; Sharaf, Naima G; Huey-Tubman, Kathryn E; Lee, Yu E; Robbiani, Davide F; Nussenzweig, Michel C; West, Anthony P; Bjorkman, Pamela J.

Nature ; 628(8008): E2, 2024 Apr.

Artigo Inglês | MEDLINE | ID: mdl-38565636

16.

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Escolano, Amelia; Gristick, Harry B; Abernathy, Morgan E; Merkenschlager, Julia; Gautam, Rajeev; Oliveira, Thiago Y; Pai, Joy; West, Anthony P; Barnes, Christopher O; Cohen, Alexander A; Wang, Haoqing; Golijanin, Jovana; Yost, Daniel; Keeffe, Jennifer R; Wang, Zijun; Zhao, Peng; Yao, Kai-Hui; Bauer, Jens; Nogueira, Lilian; Gao, Han; Voll, Alisa V; Montefiori, David C; Seaman, Michael S; Gazumyan, Anna; Silva, Murillo; McGuire, Andrew T; Stamatatos, Leonidas; Irvine, Darrell J; Wells, Lance; Martin, Malcolm A; Bjorkman, Pamela J; Nussenzweig, Michel C.

Nature ; 570(7762): 468-473, 2019 06.

Artigo Inglês | MEDLINE | ID: mdl-31142836

17.

Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.

Barnes, Christopher O; Calero, Monica; Malik, Indranil; Graham, Brian W; Spahr, Henrik; Lin, Guowu; Cohen, Aina E; Brown, Ian S; Zhang, Qiangmin; Pullara, Filippo; Trakselis, Michael A; Kaplan, Craig D; Calero, Guillermo.

Mol Cell ; 59(2): 258-69, 2015 Jul 16.

Artigo Inglês | MEDLINE | ID: mdl-26186291

18.

Publisher Correction: Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.

De Gasparo, Raoul; Pedotti, Mattia; Simonelli, Luca; Nickl, Petr; Muecksch, Frauke; Cassaniti, Irene; Percivalle, Elena; Lorenzi, Julio C C; Mazzola, Federica; Magrì, Davide; Michalcikova, Tereza; Haviernik, Jan; Honig, Vaclav; Mrazkova, Blanka; Polakova, Natalie; Fortova, Andrea; Tureckova, Jolana; Iatsiuk, Veronika; Di Girolamo, Salvatore; Palus, Martin; Zudova, Dagmar; Bednar, Petr; Bukova, Ivana; Bianchini, Filippo; Mehn, Dora; Nencka, Radim; Strakova, Petra; Pavlis, Oto; Rozman, Jan; Gioria, Sabrina; Sammartino, Josè Camilla; Giardina, Federica; Gaiarsa, Stefano; Pan-Hammarström, Qiang; Barnes, Christopher O; Bjorkman, Pamela J; Calzolai, Luigi; Piralla, Antonio; Baldanti, Fausto; Nussenzweig, Michel C; Bieniasz, Paul D; Hatziioannou, Theodora; Prochazka, Jan; Sedlacek, Radislav; Robbiani, Davide F; Ruzek, Daniel; Varani, Luca.

Nature ; 597(7874): E2, 2021 Sep.

Artigo Inglês | MEDLINE | ID: mdl-34345019

19.

The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity.

Barnes, Christopher O; Wu, Ying; Song, Jinhu; Lin, Guowu; Baxter, Elizabeth L; Brewster, Aaron S; Nagarajan, V; Holmes, Andrew; Soltis, S Michael; Sauter, Nicholas K; Ahn, Jinwoo; Cohen, Aina E; Calero, Guillermo.

Proc Natl Acad Sci U S A ; 116(19): 9333-9339, 2019 05 07.

Artigo Inglês | MEDLINE | ID: mdl-31019074

20.

An engineered transforming growth factor ß (TGF-ß) monomer that functions as a dominant negative to block TGF-ß signaling.

Kim, Sun Kyung; Barron, Lindsey; Hinck, Cynthia S; Petrunak, Elyse M; Cano, Kristin E; Thangirala, Avinash; Iskra, Brian; Brothers, Molly; Vonberg, Machell; Leal, Belinda; Richter, Blair; Kodali, Ravindra; Taylor, Alexander B; Du, Shoucheng; Barnes, Christopher O; Sulea, Traian; Calero, Guillermo; Hart, P John; Hart, Matthew J; Demeler, Borries; Hinck, Andrew P.

J Biol Chem ; 292(17): 7173-7188, 2017 04 28.

Artigo Inglês | MEDLINE | ID: mdl-28228478

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